The painful reality is that age-related cognitive decline often begins in your late 40s. Diet, exercise, nutraceuticals, and other longevity treatments may help delay this deterioration, which is particularly pronounced in declarative memory — the ability to recall facts and experiences — but age eventually takes its toll. Changes occur in gene expression in the brain’s hippocampus and frontal lobe. However, the molecular mechanisms underlying these changes in gene regulation are not completely known.
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