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Gene That Allows Worms to Grow New Head and Brain Discovered (Is this not old news? wasting taxpayers money again?) *LINK*

Gene That Allows Worms to Grow New Head and Brain Discovered

ScienceDaily (Apr. 24, 2010) — Scientists at The University of Nottingham have discovered the gene that enables an extraordinary worm to regenerate its own body parts after amputation -- including a whole head and brain.

Their research into the Planarian worm is another piece in the scientific jigsaw that could one day make the regeneration of old or damaged human organs and tissues a real possibility.

The research led by Dr Aziz Aboobaker, a Research Councils UK Fellow in the School of Biology shows for the first time that a gene called 'Smed-prep' is essential for correctly regenerating a head and brain in planarian worms. The study is published on April 22 2010 in the open access journal PLoS Genetics.

Planarian worms have an amazing ability to regenerate body parts, including a head and brain, following amputation. These remarkable creatures contain adult stem cells that are constantly dividing and can become all of the missing cell types. They also have the right set of genes working to make this happen exactly as it should so that when they re-grow body parts they end up in the right place and have the correct size, shape and orientation.

Dr Aboobaker said: "These amazing worms offer us the opportunity to observe tissue regeneration in a very simple animal that can regenerate itself to a remarkable extent and does so as a matter of course.

"We want to be able to understand how adult stem cells can work collectively in any animal to form and replace damaged or missing organs and tissues. Any fundamental advances in understanding from other animals can become relevant to humans surprisingly quickly.

"If we know what is happening when tissues are regenerated under normal circumstances, we can begin to formulate how to replace damaged and diseased organs, tissues and cells in an organised and safe way following an injury caused by trauma or disease. This would be desirable for treating Alzheimer's disease, for example. With this knowledge we can also assess the consequences of what happens when stem cells go wrong during the normal processes of renewal -- for example in the blood cell system where rogue stem cells can result in Leukaemia."

Smed-prep is necessary for the correct differentiation and location of the cells that make up a planarian worm's head. It is also sufficient for defining where the head should be located on the worm. The team have found that although the presence of Smed-prep is vital so that the head and brain are in the right place, the worm stem cells can still be persuaded to form brain cells as a result of the action of other unrelated genes. But even so, without Smed-prep these cells do not organise themselves to form a normal brain.

Daniel Felix, a graduate student who carried out the experimental work said: "The understanding of the molecular basis for tissue remodeling and regeneration is of vital importance for regenerative medicine. Planarians are famous for their immense power of regeneration, being able to regenerate a new head after decapitation. With the homeobox gene Smed-prep, we have characterised the first gene necessary for correct anterior fate and patterning during regeneration. It has been a really exciting project and I feel very lucky to have had this study as the centre piece of my thesis work"

Worm Head pictures

Worm Head

By God it works!

(BTW yur image uploader does not work!!!!!!!!!!!!!!!!!!!!!!!!

Basicly have to highlight a picture and copy and paste ----- Most frustrating!)

Messages In This Thread

Gene That Allows Worms to Grow New Head and Brain Discovered (Is this not old news? wasting taxpayers money again?) *LINK*
I can upload an image via the Optional Image Filename (and click browse to locate file on your computer) *NM* *PIC*
And I can insert image with iManager (after using it first to upload said image)
I know it sounds terribly stupid on my part, but I do follow ALL the instructions to a tee, but get error message "no image selected". I am not dah! ~ guess someone/something is playing with me
Go to Optional Image Filename, then click on 'Browse' and choose the file from your disk then ... :)
I'm doing ALL that Dancer. Trust me! The picture just does not come up in the view pane even though I selected a picture in a file - we'll just pass on this might work nxt week again. *NM*
The upload of pics seems to be blocked on your side, certainly not by TNT ... but by your PC, could be your firewall or some other 'anti-malware'. Can you disable step-by-step and then try again?
Me too - can upload via Optional Image and iManager ... maybe a specific gene is missing at your side? PicPrep? LoadStep? HastyPasty757? *PIC*
I've been in their face rather vocally, and I guess in general they just dont' like my .....
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